While Thor was away fighting Gorr, Jane was diagnosed with breast cancer. She was dating a man named Walter. She later accepted Thor's invitation to represent Midgard in the Congress of the Worlds on Asgard while she underwent therapy, but refused magical treatments.

During a battle against Nick Fury, Thor lost the ability to wield his hammer Mjolnir. The hammer remained on the Moon, where Thor and the Asgardians remained for some time, as he was unwilling to accept his loss, and attempted numerous times to lift the hammer to no avail. Soon after Thor and the rest of the Asgardians had left the Moon, Jane Foster came and picked up Mjolnir.[44] She had watched Thor use his hammer and slowly learned how to use Mjolnir by example. She traveled to Earth and came across the frozen Pacific Ocean and entered the frost giants' cave where multiple Asgardian warriors and Earthly heroes had been defeated and frozen.

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